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Cognitive performance of primary open-angle glaucoma and normal-tension glaucoma patients / Desempenho cognitivo em pacientes com glaucoma primário de ângulo aberto e glaucoma de pressão normal
Bulut, Mehmet; Yaman, Aylin; Erol, Muhammet Kazim; Kurtuluş, Fatma; Toslak, Devrim; Coban, Deniz Turgut; Başar, Ebru Kaya.
  • Bulut, Mehmet; Antalya Training and Research Hospital. Ophthalmology Department. Antalya. TR
  • Yaman, Aylin; Antalya Training and Research Hospital. Ophthalmology Department. Antalya. TR
  • Erol, Muhammet Kazim; Antalya Training and Research Hospital. Ophthalmology Department. Antalya. TR
  • Kurtuluş, Fatma; Antalya Training and Research Hospital. Ophthalmology Department. Antalya. TR
  • Toslak, Devrim; Antalya Training and Research Hospital. Ophthalmology Department. Antalya. TR
  • Coban, Deniz Turgut; Antalya Training and Research Hospital. Ophthalmology Department. Antalya. TR
  • Başar, Ebru Kaya; Antalya Training and Research Hospital. Ophthalmology Department. Antalya. TR
Arq. bras. oftalmol ; 79(2): 100-104, Mar.-Apr. 2016. tab, graf
Article in English | LILACS | ID: lil-782793
ABSTRACT
ABSTRACT

Purpose:

To assess cognitive performance differences among primary open-angle glaucoma (POAG) patients, normal-tension glaucoma (NTG) patients, and healthy control (C) subjects.

Methods:

A total of 60 participants (20 POAG, 20 NTG, and 20 C subjects) were included in this study. A detailed ophthalmologic examination was performed on all participants. A spectral domain-optical coherence tomography (SD-OCT) system was used to measure the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) thicknesses. To assess the cognitive performance of all participants, detailed neurological examinations, including the mini-mental state examination (MMSE), were performed by the same neurologist.

Results:

There were no significant differences among the groups in terms of age (p =0.348) or gender (p =0.935). The mean RNFL thicknesses were significantly different among the groups (85.2 ± 14.7, 76.8 ± 10.3, and 91.4 ± 7.7 µm in the POAG, NTG, and C subjects, respectively; p <0.001). The mean GC-IPL thicknesses were 77.5 ± 9.7 µm in the POAG group, 73.4 ± 7.8 µm in the NTG group, and 78.8 ± 3.8 µm in the C group. Differences among the groups were not statistically significant (p =0.085). MMSE scores were 26.1 ± 1.4, 25.7 ± 2.3, and 28.8 ± 0.9 in the POAG, NTG, and C groups, respectively. There were significant differences among the three groups (p <0.001). Specifically, there were significant differences between the NTG and C groups (p <0.001), and between the POAG and C groups (p =0.001). There was no significant difference between the POAG and NTG groups (p =0.595).

Conclusions:

There appear to be similar risk factors in glaucoma and neurodegenerative disorders that cause deterioration in cognitive performance. Comparing the low MMSE scores of the POAG and NTG patients with the scores of healthy C participants supports our hypothesis. Consequently, it is recommended that a neurologist should also examine glaucoma patients.
RESUMO
RESUMO

Objetivos:

Avaliar as diferenças de desempenho cognitivo entre pacientes com glaucoma primário de ângulo aberto (POAG), glaucoma de pressão normal (NTG) e controle de indivíduos saudáveis (C).

Métodos:

Um total de 60 pessoas (20 POAG, 20 NTG e 20 indivíduos saudáveis) foram incluídos neste estudo. Um exame oftalmológico detalhado foi realizado em todos os participantes. Um sistema de tomografia de coerência óptica de domínio espectral (SD-OCT) foi utilizado para medir as espessuras da camada de células ganglionares plexiforme interna (GC-IPL) e da camada de fibras nervosas da retina (RNFL). Para avaliar o desempenho cognitivo de todos os participantes, foi realizado pelo mesmo neurologista um exame neurológico detalhado, incluindo mini-exame do estado mental (MMSE).

Resultados:

Não houve diferenças significativas entre os grupos em termos de idade (p=0,348) e sexo (p=0,935). Espessuras médias da RNFL foram significativamente diferentes, sendo 85,2 ± 14,7, 76,8 ± 10,3 e 91,4 ± 7,7 µm nos grupos POAG, NTG e controles, respectivamente (p<0,001). As espessuras médias da GC-IPL observadas foram 77.5 ± 9.7 μm no grupo POAG, 73,4 ± 7,8 µm no grupo NTG e 78,8 ± 3,8 µm nos controlos. As diferenças entre os grupos não foram estatisticamente significantes (p=0,085). Graduações do MMSE foram 26,1 ± 1,4, 25,7 ± 2,3 e 28,8 ± 0,9 nos grupos POAG, NTG e controles, respectivamente. Houve diferenças significativas entre os três grupos (p<0,001). Houve diferença significativa entre NTG e saudáveis (p<0,001). Houve diferença significativa entre POAG e saudáveis (p=0,001). Não houve diferença significativa entre o POAG e NTG (p=0,595).

Conclusões:

Parecem haver fatores de risco semelhantes no glaucoma e nos distúrbios neurodegenerativos que causam deterioração no desempenho cognitivo. Comparando a baixa graduação do MMSE de pacientes com POAG e NTG com controles saudáveis referenda nossa hipótese. Consequentemente recomenda-se que um neurologista também examine os pacientes de glaucoma.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Glaucoma, Open-Angle / Cognition / Low Tension Glaucoma / Mental Status Schedule Type of study: Diagnostic study / Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2016 Type: Article Affiliation country: Turkey Institution/Affiliation country: Antalya Training and Research Hospital/TR

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Full text: Available Index: LILACS (Americas) Main subject: Glaucoma, Open-Angle / Cognition / Low Tension Glaucoma / Mental Status Schedule Type of study: Diagnostic study / Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Arq. bras. oftalmol Journal subject: Ophthalmology Year: 2016 Type: Article Affiliation country: Turkey Institution/Affiliation country: Antalya Training and Research Hospital/TR