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Medication-related osteonecrosis of the jaw. Introduction of a new modified experimental model
Curra, Cláudia; Cardoso, Camila Lopes; Ferreira Júnior, Osny; Curi, Marcos Martins; Matsumoto, Mariza Akemi; Cavenago, Bruno Cavalini; Santos, Pâmela Letícia dos; Santiago Júnior, Joel Ferreira.
  • Curra, Cláudia; Universidade Sagrado Coração. Department of Oral Surgery. Bauru. BR
  • Cardoso, Camila Lopes; Universidade Sagrado Coração. Department of Oral Surgery. Bauru. BR
  • Ferreira Júnior, Osny; Universidade Sagrado Coração. Department of Oral Surgery. Bauru. BR
  • Curi, Marcos Martins; Universidade Sagrado Coração. Department of Oral Surgery. Bauru. BR
  • Matsumoto, Mariza Akemi; Universidade Sagrado Coração. Department of Oral Surgery. Bauru. BR
  • Cavenago, Bruno Cavalini; Universidade Sagrado Coração. Department of Oral Surgery. Bauru. BR
  • Santos, Pâmela Letícia dos; Universidade Sagrado Coração. Department of Oral Surgery. Bauru. BR
  • Santiago Júnior, Joel Ferreira; Universidade Sagrado Coração. Department of Oral Surgery. Bauru. BR
Acta cir. bras ; 31(5): 308-313, May 2016. tab, graf
Article in English | LILACS | ID: lil-783798
ABSTRACT
ABSTRACT

PURPOSE:

To evaluate a modified experimental model for medication-related osteonecrosis of the jaw (MRONJ) through the upper right central incisor extraction followed by intravenous bisphosphonate administration.

METHODS:

Forty five rats underwent the upper right central incisor tooth extraction were divided in 2 groups Group I - experimental group, 30 rats received an intravenous administration protocol of zoledronic acid 35μg/kg into the tail vein every two weeks, totalizing four administrations, during eight weeks of administration, previously the extraction, and Group II - control group, 15 rats didn't received any medication before extraction. The groups were subdivided in postoperative periods 14/28/42 days. Clinical analysis and microtomography were performed to verify the presence of osteonecrosis. In addition, descritive histological analysis of hematoxylin-eosin stained sections was performed to evaluate the presence of osteonecrosis or necrotic foci.

RESULTS:

Twelve (40%) rats, from experimental group, showed clinical signs of MRONJ (p=0.005), however, all samples showed imaginologic findings like osteolysis and loss of integrity of the cellular walls (p≤0.001). Microscopic evaluation revealed osteonecrosis areas with microbial colonies and inflammatory infiltrate (p≤0.001). In the control group, all animals presented the chronology of a normal wound healing.

CONCLUSIONS:

The presence of medication-related osteonecrosis of the jaw after maxillary central incisor extraction in rats. This new experimental model may be considered an option for the study of MRONJ.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Models, Animal / Diphosphonates / Bisphosphonate-Associated Osteonecrosis of the Jaw / Imidazoles Type of study: Practice guideline / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Sagrado Coração/BR

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Full text: Available Index: LILACS (Americas) Main subject: Models, Animal / Diphosphonates / Bisphosphonate-Associated Osteonecrosis of the Jaw / Imidazoles Type of study: Practice guideline / Prognostic study Limits: Animals Language: English Journal: Acta cir. bras Journal subject: General Surgery / Procedimentos Cir£rgicos Operat¢rios Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Sagrado Coração/BR