Tratamiento con sirolimus y prednisona en enfermedad de Erdheim-Chester con compromiso cardiaco: caso clínico / Sirolimus and prednisone for the treatment of Erdheim-Chester disease with cardiac involvement: report of one case
Rev. méd. Chile
;
144(3): 394-400, mar. 2016. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-784911
ABSTRACT
Erdheim-Chester disease (ECD) is a rare non-Langerhans histiocytic disorder. We report a 76-years-old man who suffered a cardiac tamponade secondary to ECD. A pericardial window was made and during the operation the surgeons observed that the myocardium was diffusely infiltrated. Twenty-eight months before, ECD was clinically diagnosed and prednisone and methotrexate were prescribed. Due to disease progression which culminated in the cardiac tamponade, methotrexate was changed to sirolimus aiming to obtain plasma levels between 5-8 ng/ml. This treatment stabilized his cardiac function allowing a survival of 52 months after its initiation, with fewer side effects.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Prednisone
/
Cardiac Tamponade
/
Sirolimus
/
Erdheim-Chester Disease
/
Anti-Inflammatory Agents
Limits:
Aged
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2016
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Naval A. Nef/CL
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