Protective effect of metformin on testicular ischemia/reperfusion injury in rats
Acta cir. bras
;
31(6): 411-416, tab, graf
Article
in English
| LILACS
| ID: lil-785016
ABSTRACT
ABSTRACT PURPOSE:
To investigate the protective effect of metformin on testicular ischemia/reperfusion (I/R) injury in rats.METHODS:
Eighteen adult male Wistar rats were randomly divided into three experimental groups (n=6), as follows Sham, I/R, and Metformin. 1-hour ischemia was induced by the left testicular artery and vein clipping followed by 7 days of reperfusion. Metformin (100 mg/kg) was administrated orally for 7 days via oral gavage after ischemic period. At the end of trial, the left testis was removed for histological analysis and oxidative stress measurement.RESULTS:
I/R reduced superoxide dismutase (SOD) activities and testicular Johnsen's scores accompanied by an elevation in malondialdehyde (MDA) and myeloperoxidase (MPO) levels in comparison with the sham group (P < 0.05). Compared to I/R group, metformin restored testicular Johnsen's scores, SOD activity, MDA and MPO levels (P < 0.05).CONCLUSION:
Metformin has a protective effect against I/R injury on the testis.
Full text:
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Index:
LILACS (Americas)
Main subject:
Testis
/
Reperfusion Injury
/
Protective Agents
/
Metformin
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2016
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Islamic Azad University/IR
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