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The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia / O efeito do extrato de semente de uva vermelha na atividade do soro paraoxonase em doentes com hiperlipidemia leve a moderada
Argani, Hassan; Ghorbanihaghjo, Amir; Vatankhahan, Hamid; Rashtchizadeh, Nadereh; Raeisi, Sina; Ilghami, Hadi.
  • Argani, Hassan; Tabriz University of Medical Sciences. Drug Applied Research Center. Tabriz. IR
  • Ghorbanihaghjo, Amir; Tabriz University of Medical Sciences. Drug Applied Research Center. Tabriz. IR
  • Vatankhahan, Hamid; Tabriz University of Medical Sciences. Drug Applied Research Center. Tabriz. IR
  • Rashtchizadeh, Nadereh; Tabriz University of Medical Sciences. Drug Applied Research Center. Tabriz. IR
  • Raeisi, Sina; Tabriz University of Medical Sciences. Drug Applied Research Center. Tabriz. IR
  • Ilghami, Hadi; Tabriz University of Medical Sciences. Drug Applied Research Center. Tabriz. IR
São Paulo med. j ; 134(3): 234-239, tab
Article in English | LILACS | ID: lil-785803
ABSTRACT
ABSTRACT CONTEXT AND

OBJECTIVE:

Red grape seed extract (RGSE) contains oligomeric proanthocyanidin complexes as a class of flavonoids. These compounds are potent antioxidants and exert many health-promoting effects. This study aimed to determine the effects of RGSE on serum levels of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein AI (apo-AI) levels and paraoxonase (PON) activity in patients with mild to moderate hyperlipidemia (MMH). DESIGN AND SETTINGS A randomized double-blind placebo-controlled clinical trial was conducted at Shahid-Modarres Hospital (Tehran, Iran) and Tabriz University of Medical Sciences. Seventy MMH patients were randomly assigned to receive treatment (200 mg/day of RGSE) or placebo for eight weeks.

RESULTS:

Significant elevation in serum levels of apo-AI (P = 0.001), HDL-C (P = 0.001) and PON activity (P = 0.001) and marked decreases in concentrations of TC (P = 0.015), TG (P = 0.011) and LDL-C (P = 0.014) were found in the cases. PON activity was significantly correlated with apo-AI (r = 0.270; P < 0.01) and HDL-C (r = 0.45; P < 0.001). Significant differences between the RGSE and control groups (before and after treatment) for TC (P = 0.001), TG (P = 0.001), PON (P = 0.03), apo-AI (P = 0.001) and LDL-C (P = 0.002) were seen.

CONCLUSION:

It is possible that RGSE increases PON activity mostly through increasing HDL-C and apo-AI levels in MMH patients. It may thus have potential beneficial effects in preventing oxidative stress and atherosclerosis in these patients.
RESUMO
RESUMO CONTEXTO E

OBJETIVO:

Extrato de semente de uva vermelha (RGSE) contém complexos de proantocianidinas oligoméricas como classe de flavonoides. Estes compostos são antioxidantes potentes e exercem muitos efeitos de promoção da saúde. Este estudo visou determinar os efeitos de RGSE nos níveis séricos de triglicérides (TG), colesterol total (TC), colesterol de lipoproteína alta-densidade (HDL-C), colesterol de lipoproteína baixa-densidade (LDL-C), apolipoproteína AI (apo-AI) e atividade de paraoxonase (PON) em pacientes com hiperlipidemia leve a moderada (MMH). DESENHO E LOCAL Estudo clínico randomizado duplo-cego controlado com placebo, realizado no Hospital Shahid-Modarres (Teerã, Irã) e na Universidade de Ciências Médicas de Tabriz. Setenta pacientes com MMH foram aleatoriamente designados para receber tratamento (200 mg/dia de RGSE) ou placebo durante oito semanas.

RESULTADOS:

Elevação significativa nos níveis séricos de apo-AI (P = 0,001), HDL-C (P = 0,001) e atividade de PON (P = 0,001) e diminuição marcada nas concentrações de TC (P = 0,015), TG (P = 0,011) e LDL-C (P = 0,014) foram encontradas nos casos. Atividade de PON mostrou correlação significativa com apo-AI (r = 0,270; P < 0,01) e HDL-C (r = 0,45; P < 0,001). Diferenças significativas entre os grupos RGSE e controle (antes e após tratamento) para TC (P = 0,001), TG (P = 0,001), PON (P = 0,03), apo-AI (P = 0,001) e LDL-C (P = 0,002) foram observadas.

CONCLUSÃO:

É possível que RGSE aumente atividade de PON principalmente através da elevação dos níveis de HDL-C e apo-AI em pacientes MMH. Ele pode, assim, ter efeitos benéficos potenciais na prevenção de estresse oxidativo e aterosclerose nesses pacientes.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Aryldialkylphosphatase / Grape Seed Extract / Hyperlipidemias / Antioxidants Type of study: Controlled clinical trial Limits: Adult / Female / Humans / Male Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2016 Type: Article Affiliation country: Iran Institution/Affiliation country: Tabriz University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Aryldialkylphosphatase / Grape Seed Extract / Hyperlipidemias / Antioxidants Type of study: Controlled clinical trial Limits: Adult / Female / Humans / Male Language: English Journal: São Paulo med. j Journal subject: Cirurgia Geral / Ciˆncia / Ginecologia / Medicine / Medicina Interna / Obstetr¡cia / Pediatria / Sa£de Mental / Sa£de P£blica Year: 2016 Type: Article Affiliation country: Iran Institution/Affiliation country: Tabriz University of Medical Sciences/IR