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Effects of sildenafil on dental pulp: immunohistochemical and ultrastructural evaluation / Efectos de sildenafil en la pulpa dental: evaluación inmunohistoquímica y ultraestructural
Söker, Sevda; Deveci, Engin; Yaman, Ferhan; Atilgan, Serhat; Ipek, Fikret; Uysal, Ibrahim.
  • Söker, Sevda; University of Dicle. Faculty of Medicine. Department of Histology and Embryology. Diyarbakir. TR
  • Deveci, Engin; University of Dicle. Faculty of Medicine. Department of Histology and Embryology. Diyarbakir. TR
  • Yaman, Ferhan; University of Dicle. Faculty of Medicine. Department of Oral and Maxillofacial Surgery. Diyarbakir. TR
  • Atilgan, Serhat; University of Dicle. Faculty of Medicine. Department of Oral and Maxillofacial Surgery. Diyarbakir. TR
  • Ipek, Fikret; University of Dicle. Faculty of Medicine. Department of Periodontology. Diyarbakir. TR
  • Uysal, Ibrahim; University of Dicle. Faculty of Medicine. Department of Endodontology. Diyarbakir. TR
Int. j. morphol ; 34(2): 570-574, June 2016. ilus
Article in English | LILACS | ID: lil-787038
ABSTRACT
Sildenafil is a strong peripheral vasodilator and is used to treat cardiovascular and neurosurgery. The purpose of this study was to investigate the immunohistochemical and ultrastructural effects of sildenafil on dental pulp of rats. The study was performed with adult female Wistar-Albino rats. Control group (n= 7) were fed on standard laboratory diet until surgery. The study group (n= 7) were administered sildenafil orally with orogastric tube 10 mg·kg-1 once a day for 30 days. Each rat was anesthetized and incisor teeth were removed. This study examined the immunohistochemical and ultrastructural effects of sildenafil on the dental pulp in rats. The relaxation from the vessel, endothelial cell hyperplasia, moderate degeneration of collagen fibers were observed to cause degenerative changes in odontoblast with sildenafil. In the pulp tissue long-term use sildenafil is thought to cause degeneration and new vessel formation.
RESUMEN
El sildenafil es un vasodilatador periférico importante y se utiliza para tratar enfermedades cardiovasculares y en neurocirugía. El propósito de este estudio fue investigar los efectos inmunohistoquímicos y ultraestructurales del sildenafil sobre la pulpa dental de ratas. El estudio se realizó con ratas Wistar albinas, hembras adultas. El grupo de control (n= 7) fue alimentado con una dieta estándar de laboratorio hasta que se realizó la cirugía. El grupo de estudio (n= 7) fue tratado con sildenafil por vía oral y sonda orogástrica 10 mg·kg-1 una vez al día durante 30 días. Cada rata fue anestesiada y se extrajeron los dientes incisivos. Se examinaron los efectos inmunohistoquímicos y ultraestructurales del sildenafil sobre la pulpa dentaria. Con la administración de sildenafil se observó la relajación de los vasos, la hiperplasia de las células endoteliales y una degeneración moderada de fibras colágenas causando cambios degenerativos en los odontoblastos. En el tejido pulpar, el uso de sildenafil a largo plazo puede causar la degeneración y neoformación de vasos.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Piperazines / Dental Pulp / Phosphodiesterase 5 Inhibitors Limits: Animals / Female / Humans Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2016 Type: Article Affiliation country: Turkey Institution/Affiliation country: University of Dicle/TR

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Full text: Available Index: LILACS (Americas) Main subject: Piperazines / Dental Pulp / Phosphodiesterase 5 Inhibitors Limits: Animals / Female / Humans Language: English Journal: Int. j. morphol Journal subject: Anatomy Year: 2016 Type: Article Affiliation country: Turkey Institution/Affiliation country: University of Dicle/TR