Association between microRNA single nucleotide polymorphisms and the risk of hepatocellular carcinoma / Asociación entre polimorfismos de un nucleótido en microRNA circulante y riesgo de carcinoma hepatocelular
Rev. méd. Chile
;
144(4): 508-515, abr. 2016. tab
Article
in Spanish
| LILACS
| ID: lil-787123
ABSTRACT
Background:
Hepatocellular carcinoma (HCC) has a high morbidity and mortality. Single nucleotide polymorphisms (SNPs) of microRNA (miRNA) may be associated with the susceptibility to develop certain malignant tumors.Aim:
To study the association between SNPs of miRNA and hepatocellular carcinoma in peripheral blood samples. Material andMethods:
Three SNPs in miRNA were studied in peripheral blood samples of 498 patients with HCC and 520 controls.Results:
A significant association was observed between rs13299349 in miRNA3152 and HCC. AA genotype or A allele were significantly associated with increased risk of HCC. A allele was associated with the size and number of tumor foci. There was also a relationship between rs10061133 in miRNA449b and HCC. The G allele was significantly associated with increased risk of HCC compared with A allele.Conclusions:
This study links rs13299349 in miRNA3152 and rs10061133 in miRNA449b with the risk of developing HCC.RESUMEN
Antecedentes El carcinoma hepatocelular (CHC) tiene una alta morbilidad y mortalidad. Polimorfismos de un nucleótido (SNP) presentes en el microRNA (miRNA) circulante pueden asociarse a ciertos tumores. Objetivo:
Estudiar la asociación entre la presencia de SNPs en miRNA circulante y la presencia de carcinoma hepatocelular. Material yMétodos:
Se determinó la presencia de tres SNP en microRNA de sangre periférica en 498 pacientes con CHC y 520 controles.Resultados:
El SNP rs13299349 en el miRNA3152 se asoció con CHC. El genotipo AA o el alelo A se asociaron con un riesgo mayor de presentar un CHC. El alelo A se asoció además con el tamaño y número de focos del tumor. Se observó también una relación entre el SNP rs10061133 en el miRNA449b y HCC. En este caso, el alelo G se relacionó con un mayor riesgo de CHC.Conclusiones:
Los SNP rs13299349 en el miRNA3152 y rs10061133 en el miRNA449b se asocian al riesgo de desarrollar CHC.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Carcinoma, Hepatocellular
/
Polymorphism, Single Nucleotide
/
MicroRNAs
/
Genetic Association Studies
/
Liver Neoplasms
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2016
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Fudan University/CN
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