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Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma
Jureidini, Ricardo; da Cunha, José Eduardo Monteiro; Takeda, Flavio; Namur, Guilherme Naccache; Ribeiro, Thiago Costa; Patzina, Rosely; Figueira, Estela RR; Ribeiro Jr, Ulysses; Bacchella, Telesforo; Cecconello, Ivan.
  • Jureidini, Ricardo; Universidade de São Paulo. Faculdade de Medicina da Universidade de São Paulo. BR
  • da Cunha, José Eduardo Monteiro; Universidade de São Paulo. Faculdade de Medicina da Universidade de São Paulo. BR
  • Takeda, Flavio; Universidade de São Paulo. Faculdade de Medicina da Universidade de São Paulo. BR
  • Namur, Guilherme Naccache; Universidade de São Paulo. Faculdade de Medicina da Universidade de São Paulo. BR
  • Ribeiro, Thiago Costa; Universidade de São Paulo. Faculdade de Medicina da Universidade de São Paulo. BR
  • Patzina, Rosely; Universidade de São Paulo. Faculdade de Medicina da Universidade de São Paulo. BR
  • Figueira, Estela RR; Universidade de São Paulo. Faculdade de Medicina da Universidade de São Paulo. BR
  • Ribeiro Jr, Ulysses; Universidade de São Paulo. Faculdade de Medicina da Universidade de São Paulo. BR
  • Bacchella, Telesforo; Universidade de São Paulo. Faculdade de Medicina da Universidade de São Paulo. BR
  • Cecconello, Ivan; Universidade de São Paulo. Faculdade de Medicina da Universidade de São Paulo. BR
Clinics ; 71(6): 315-319, tab, graf
Article in English | LILACS | ID: lil-787421
ABSTRACT

OBJECTIVE:

To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer.

METHODS:

Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope.

RESULTS:

The microvessel density ranged from 21.2 to 54.2 vessels/mm2. Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure.

CONCLUSIONS:

Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Pancreatic Neoplasms / Tumor Suppressor Protein p53 / Carcinoma, Pancreatic Ductal / Microvessels Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Pancreatic Neoplasms / Tumor Suppressor Protein p53 / Carcinoma, Pancreatic Ductal / Microvessels Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de São Paulo/BR