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Prognostic value of cystatin C in patients with nasopharyngeal carcinoma: a retrospective study of 1063 patients
Yuan, Jing; Xu, Miao; Li, Jing; Li, Ning; Chen, Li-Zhen; Feng, Qi-Sheng; Zeng, Yi-Xin.
  • Yuan, Jing; Sun Yat-sen University. Department of Experimental Research. State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine. Guangzhou. CN
  • Xu, Miao; Sun Yat-sen University. Department of Experimental Research. State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine. Guangzhou. CN
  • Li, Jing; Sun Yat-sen University. Department of Experimental Research. State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine. Guangzhou. CN
  • Li, Ning; Sun Yat-sen University. Department of Experimental Research. State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine. Guangzhou. CN
  • Chen, Li-Zhen; Sun Yat-sen University. Department of Experimental Research. State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine. Guangzhou. CN
  • Feng, Qi-Sheng; Sun Yat-sen University. Department of Experimental Research. State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine. Guangzhou. CN
  • Zeng, Yi-Xin; Sun Yat-sen University. Department of Experimental Research. State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine. Guangzhou. CN
Clinics ; 71(6): 338-343, tab, graf
Article in English | LILACS | ID: lil-787428
ABSTRACT

OBJECTIVE:

Patients with nasopharyngeal carcinoma experience highly variable outcomes despite receiving similar therapeutic regimens. Identifying biomarkers that predict survival and guide individualized therapy is urgently needed. Cystatin C has been explored as a valuable prognostic marker in several malignancies. We retrospectively assessed the relationship between serum cystatin C levels and nasopharyngeal carcinoma prognosis in a large cohort of nasopharyngeal carcinoma patients receiving long-term follow-up.

METHODS:

A total of 1063 consecutive patients diagnosed with nasopharyngeal carcinoma from June 2006 to December 2010 were retrospectively analyzed. The serum levels of cystatin C at the time of diagnosis were collected. Receiver operating characteristic curve analysis, the Kaplan-Meier method and multivariate analyses using a Cox regression model were performed to assess the correlation of cystatin C levels with overall survival, progression-free survival, distant metastasis-free survival and loco-regional recurrence-free survival.

RESULTS:

The median follow-up duration was 68.3 months. The optimal cut-off value of cystatin C levels for predicting death was 0.945 mg/L. Compared with the low cystatin C group, the high cystatin C group experienced significantly shorter overall survival (hazard ratio=1.47, p=0.050), progression-free survival (hazard ratio=1.65, p=0.004), distant metastasis-free survival (hazard ratio=2.37, p<0.001) and loco-regional recurrence-free survival (hazard ratio=2.40, p=0.002). Based on multivariate analysis, a high cystatin C level was identified as a significant and independent negative predictor of overall survival (hazard ratio=1.47, p=0.050), progression-free survival (hazard ratio=1.65, p=0.004), distant metastasis-free survival (hazard ratio=2.37, p<0.001), and loco-regional recurrence-free survival (hazard ratio=2.40, p=0.002).

CONCLUSION:

Cystatin C levels are associated with the prognosis of nasopharyngeal carcinoma patients. A high cystatin C level is an independent indicator of poor prognosis for nasopharyngeal carcinoma patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Carcinoma / Biomarkers, Tumor / Nasopharyngeal Neoplasms / Cystatin C Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2016 Type: Article Affiliation country: China Institution/Affiliation country: Sun Yat-sen University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Carcinoma / Biomarkers, Tumor / Nasopharyngeal Neoplasms / Cystatin C Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2016 Type: Article Affiliation country: China Institution/Affiliation country: Sun Yat-sen University/CN