Control de la ingesta alimentaria: rol del receptor 4 de melanocortina en el desarrollo de obesidad / Role of melanocortin receptor 4 in the control of food intake and the development of obesity
Rev. chil. endocrinol. diabetes
;
8(1): 19-24, ene.2015.
Article
in Spanish
| LILACS
| ID: lil-789319
ABSTRACT
Arquate nucleus, a convergence site of peripheral and central signals, plays a fundamental role in the control of food intake. Orexigenic neurons that secrete neuropeptide Y (NPY) and Agouti-related peptide (AgRP) and anorexigenic neurons secreting Pro-opiomelanocortin (POMC) are involved in this action. Both groups of neurons respond to peripheral signals such as insulin and leptin and are reciprocally inhibited. alpha Type melanocyte stimulating hormone (alphaMSH), liberated by POMC neurons, reduces food intake activating melanocortin receptor 4 (MC4R), located in second order neurons of the paraventricular nucleus. NPY/AgRP antagonize the effects of this peptide on MC4R receptors,maintaining an inhibitory tone on áMHS liberation, mediated by the activation of gabaergic receptors of POMC neurons. The study of these mechanisms will allow the development of new medications, especially MC4R agonists, to reduce nutrient intake...
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Energy Intake
/
Eating
/
Obesity
Limits:
Humans
Language:
Spanish
Journal:
Rev. chil. endocrinol. diabetes
Journal subject:
Endocrinology
Year:
2015
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad San Sebastián/CL
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