Oxidative stress in carotid arteries of patients submitted to carotid endarterectomy. The role of aging process
Acta cir. bras
;
31(8): 564-568, Aug. 2016. tab, graf
Article
in English
| LILACS
| ID: lil-792407
ABSTRACT
ABSTRACT PURPOSE:
To evaluated the role of oxidative stress on aging process in patients submitted to carotid endarterectomy.METHODS:
Twenty patients were divided into two groups older group (≥ 70 years old); and the younger group (< 70 years old). We evaluated the reactive oxygen species (ROS) concentration, nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, superoxide dismutase (SOD) and catalase (CAT) activities as so as nitrite levels in fragments of carotid arteries harvested during carotid endarterectomy for treatment of high grade carotid stenosis.RESULTS:
We observed a higher levels of ROS and NADPH oxidase activity in the older group (p<0.05). Furthermore, the nitrite concentration was lower in the older group (14.55 ± 5.61 x 10-3 versus 26.42 ± 8.14 x 10-3 µM; p=0.0123). However, the activities of antioxidant enzymes (CAT and SOD) were similar in both the groups.CONCLUSIONS:
Arterial aging is associated with increased concentrations of oxygen species and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity as so as nitrite reduction in human carotid artery specimens. Maybe therapies that block NADPH oxidase activity and enhance nitrite stores would be a good strategy to reduce the effect of oxidative stress in arterial aging.
Full text:
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Index:
LILACS (Americas)
Main subject:
Aging
/
Carotid Arteries
/
Endarterectomy, Carotid
/
Oxidative Stress
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Ciências da Saúde de Porto Alegre/BR
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