Effect of aqueous extract of the Vigna angularis in rats subjected to an experimental model of moderate chronic kidney disease
Acta cir. bras
;
31(8): 527-532, Aug. 2016. graf
Article
in English
| LILACS
| ID: lil-792410
ABSTRACT
ABSTRACT PURPOSE:
To evaluate the effect of the aqueous extract of the Vigna angularis, popularly known as "Azuki beans", in rats subjected to an experimental model of moderate chronic kidney disease.METHODS:
Thirty rats underwent two surgeries - Ormrod and Miller (1980) - to obtain Moderate Chronic Kidney Disease (CKD-M). The animals were randomized into 3 groups. Group 1 (Control) distilled water. Group 2 (Azuki) Vigna angularis 5% aqueous extract. Group 3 (Treatment) 10mg/kg of enalapril maleate. The rats received their respective treatments for 14 days.RESULTS:
The treatment with azuki beans produced an increase in urine output from the second day until the end of the experiment compared to the Control groups (p<0.01) and Treatment (p<0.05). The treatment with azuki also produced significant reductions in the levels of glucose, triglycerides, VLDL, uric acid, Alanine aminotransferase (p<0.05), urea and serum creatinine (p<0.01), besides having produced a significant increase in the levels of HDL when compared to the Control group.CONCLUSION:
Treatment with Azuki beans produced improvements in the parameters of renal function and significantly reduced glucose levels, triglycerides, VLDL, alanine aminostransferase, uric acid and creatinine, besides having produced a significant increase in the levels of HDL in rats submitted to a model of moderate chronic kidney disease.
Full text:
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Index:
LILACS (Americas)
Main subject:
Plant Extracts
/
Renal Insufficiency, Chronic
/
Vigna
/
Phytotherapy
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Medical School of Itajubá/BR
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