The beneficial effects of Montelukast against 2 3 7 8 tetrachlorodibenzo dioxin toxicity in female reproductive system in rats
Acta cir. bras
;
31(8): 557-563, Aug. 2016. tab, graf
Article
in English
| LILACS
| ID: lil-792413
ABSTRACT
ABSTRACT PURPOSE:
To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis.METHODS:
Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed.RESULTS:
The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment.CONCLUSION:
The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Ovary
/
Quinolines
/
Oxidative Stress
/
Polychlorinated Dibenzodioxins
/
Acetates
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2016
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
University of Inonu/TR
Similar
MEDLINE
...
LILACS
LIS