Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis
An. bras. dermatol
;
91(4): 463-467, July-Aug. 2016. tab, graf
Article
in English
| LILACS
| ID: lil-792441
ABSTRACT
Abstract Background:
The studies found in the literature associate the immunoexpression of hMLH1 and hMSH2 proteins with histologic aspects, but do not correlate it with clinical and epidemiological data.Objective:
To evaluate the immunoexpression of hMLH1 and hMSH2 in actinic cheilitis, correlating it with clinical characteristics.Methods:
We analyzed 40 cases. Histological and immunohistochemical analyses were performed. The following clinical variables were evaluated gender, age range, ethnicity, clinical aspect and occupational sunlight exposure. Statistical evaluation included the Student t-test, while the significance level was set at 5%.Results:
Greater immunoexpression of hMLH1 and hMSH2 was observed in females, individuals aged over 40, and mixed-race/black patients. Furthermore, the immunoexpression of these proteins was greater in actinic cheilitis with a white-colored appearance and in patients without occupational sunlight exposure. No statistical differences were observed for the variables studied.Conclusion:
This study uncovered variations of hMLH1 and hMSH2 protein expression upon evaluation of clinical aspects in actinic cheilitis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Cheilitis
/
MutS Homolog 2 Protein
/
MutL Protein Homolog 1
Type of study:
Etiology study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
An. bras. dermatol
Journal subject:
Dermatology
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual da Paraíba/BR
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