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Can procalcitonin be a diagnostic marker for catheter-related blood stream infection in children? / A procalcitonina pode ser um marcador de diagnóstico de infecções de corrente sanguínea relacionadas a cateter em crianças?
Ozsurekci, Yasemin; Arıkan, Kamile Oktay; Bayhan, Cihangül; Karadağ-Öncel, Eda; Aycan, Ahmet Emre; Gürbüz, Venhar; Hasçelik, Gülşen; Ceyhan, Mehmet.
  • Ozsurekci, Yasemin; Hacettepe University. Faculty of Medicine. Department of Pediatric Infectious Diseases. Ankara. TR
  • Arıkan, Kamile Oktay; Hacettepe University. Faculty of Medicine. Department of Pediatric Infectious Diseases. Ankara. TR
  • Bayhan, Cihangül; Hacettepe University. Faculty of Medicine. Department of Pediatric Infectious Diseases. Ankara. TR
  • Karadağ-Öncel, Eda; Hacettepe University. Faculty of Medicine. Department of Pediatric Infectious Diseases. Ankara. TR
  • Aycan, Ahmet Emre; Hacettepe University. Faculty of Medicine. Department of Pediatric Infectious Diseases. Ankara. TR
  • Gürbüz, Venhar; Hacettepe University. Faculty of Medicine. Department of Pediatric Infectious Diseases. Ankara. TR
  • Hasçelik, Gülşen; Hacettepe University. Faculty of Medicine. Department of Pediatric Infectious Diseases. Ankara. TR
  • Ceyhan, Mehmet; Hacettepe University. Faculty of Medicine. Department of Pediatric Infectious Diseases. Ankara. TR
J. pediatr. (Rio J.) ; 92(4): 414-420, July-Aug. 2016. tab, graf
Article in English | LILACS | ID: lil-792583
ABSTRACT
Abstract Objective The potential role of procalcitonin (PCT) in the diagnosis of catheter-related bloodstream infection (CRBSIs) is still unclear and requires further research. The diagnostic value of serum PCT for the diagnosis of CRBSI in children is evaluated here. Method This study was conducted between October 2013 and November 2014, and included patients with suspected CRBSI from 1 month to 18 years of age who were febrile, with no focus of infection, and had a central venous catheter. Levels of PCT and other serum markers were measured, and their utility as CRBSI markers was assessed. Additionally, the clinical performance of a new, automated, rapid, and quantitative assay for the detection of PCT was tested. Results Among the 49 patients, 24 were diagnosed with CRBSI. The PCT-Kryptor and PCT-RTA values were significantly higher in proven CRBSI compared to those in unproven CRBSI (p = 0.03 and p = 0.03, respectively). There were no differences in white blood cell count and C-reactive protein (CRP) levels between proven CRBSI and unproven CRBSI. Among the 24 patients with CRBSI, CRP was significantly higher among those with Gram-negative bacterial infection than in those with Gram-positive bacterial infections. PCT-Kryptor was also significantly higher among patients with Gram-negative bacterial infection than in those with Gram-positive bacterial infections (p = 0.01 and p = 0.02, respectively). Conclusions The authors suggest that PCT could be a helpful rapid diagnostic marker in children with suspected CRBSIs.
RESUMO
Resumo Objetivo O possível papel da procalcitonina (PCT) no diagnóstico de infecções de corrente sanguínea relacionadas a cateter (ICSRCs) ainda não está claro e precisa ser mais pesquisado. O valor diagnóstico da PCT sérica para o diagnóstico de ICSRC em crianças é avaliado neste estudo. Método Este estudo foi feito entre outubro de 2013 e novembro de 2014 e incluiu pacientes com suspeita de ICSRC de um mês a 18 anos que estavam febris, não tinham foco de infecção e tinham cateter venoso central. Foram medidos os níveis de PCT e de outros marcadores séricos, cuja utilidade como marcadores de ICSRC foi avaliada. Adicionalmente, foi testado o desempenho clínico de um novo ensaio quantitativo automatizado e rápido para a detecção de PCT. Resultados Dentre 49 pacientes, 24 foram diagnosticados com ICSRC. Os valores de PCT-Kryptor e PCT-RTA foram significativamente maiores em ICSRCs comprovadas do que em ICSRCs não comprovadas (p = 0,03 e p = 0,03, respectivamente). Não houve diferença na contagem de glóbulos brancos e nos níveis de proteína C reativa (PCR) entre ICSRCs comprovadas e ICSRCs não comprovadas. Dentre os 24 pacientes com ICSRC, a PCR era significativamente maior entre aqueles com infecção bacteriana gram-negativa do que naqueles com infecção bacteriana gram-positiva. O PCT-Kryptor também foi significativamente maior entre pacientes com infecção por bactérias gram-negativas do que naqueles com infecção por bactérias gram-positivas (p = 0,01 e p = 0,02, respectivamente). Conclusões Sugerimos que a PCT pode ser um marcador de diagnóstico rápido útil em crianças com suspeita de ICSRCs.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Calcitonin / Bacteremia / Catheter-Related Infections Type of study: Diagnostic study / Evaluation studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2016 Type: Article Affiliation country: Turkey Institution/Affiliation country: Hacettepe University/TR

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Full text: Available Index: LILACS (Americas) Main subject: Calcitonin / Bacteremia / Catheter-Related Infections Type of study: Diagnostic study / Evaluation studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: English Journal: J. pediatr. (Rio J.) Journal subject: Pediatrics Year: 2016 Type: Article Affiliation country: Turkey Institution/Affiliation country: Hacettepe University/TR