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Immunoexpression of cleaved caspase-3 shows lower apoptotic area indices in lip carcinomas than in intraoral cancer
LEITE, Ana Flávia Schueler de Assumpção; BERNARDO, Vagner Gonçalves; BUEXM, Luisa Aguirre; FONSECA, Eliene Carvalho da; SILVA, Licínio Esmeraldo da; BARROSO, Danielle Resende Camisasca; LOURENÇO, Simone de Queiroz Chaves.
  • LEITE, Ana Flávia Schueler de Assumpção; Universidade Federal Fluminense. Faculdade de Odontologia. Niterói. BR
  • BERNARDO, Vagner Gonçalves; Universidade Federal Fluminense. Faculdade de Odontologia. Niterói. BR
  • BUEXM, Luisa Aguirre; Universidade Federal Fluminense. Faculdade de Odontologia. Niterói. BR
  • FONSECA, Eliene Carvalho da; Universidade Federal Fluminense. Faculdade de Odontologia. Niterói. BR
  • SILVA, Licínio Esmeraldo da; Universidade Federal Fluminense. Faculdade de Odontologia. Niterói. BR
  • BARROSO, Danielle Resende Camisasca; Universidade Federal Fluminense. Faculdade de Odontologia. Niterói. BR
  • LOURENÇO, Simone de Queiroz Chaves; Universidade Federal Fluminense. Faculdade de Odontologia. Niterói. BR
J. appl. oral sci ; 24(4): 359-365, July-Aug. 2016. tab, graf
Article in English | LILACS, BBO | ID: lil-792590
ABSTRACT
ABSTRACT Objective This study aimed to evaluate apoptosis by assessing cleaved caspase-3 immunoexpression in hyperplastic, potentially malignant disorder (PMD), and malignant tumors in intraoral and lower lip sites. Material and Methods A retrospective study using paraffin blocks with tissues from patients with inflammatory fibrous hyperplasia (IFH), actinic cheilitis, oral leukoplakia, lower lip and intraoral squamous cell carcinoma (SCC) was performed. The tissues were evaluated by immunohistochemical analysis with anti-cleaved caspase-3 antibody. Apoptotic area index was then correlated with lesion type. Results From 120 lesions assessed, 55 (46%) were cleaved caspase-3-positive. The SCC samples (n=40) had the highest apoptotic area indices (n=35; 87.5%). Significant differences were detected between SCCs and PMDs (p=0.0003), as well as SCCs and IFHs (p=0.001), regarding caspase-3 immunopositivity. Carcinomas of the lower lip had lower apoptotic area indices than intraoral cancer (p=0.0015). Conclusions Cleaved caspase-3 immunoexpression showed differences in oral SCCs and PMDs and demonstrated a distinct role of apoptosis in carcinogenesis of intraoral and lower lip cancer. In future, the expression of cleaved caspase-3 with other target molecules in oral cancer may be helpful in delineating the prognosis and treatment of these tumors.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Leukoplakia, Oral / Lip Neoplasms / Mouth Neoplasms / Carcinoma, Squamous Cell / Apoptosis / Caspase 3 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal Fluminense/BR

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Full text: Available Index: LILACS (Americas) Main subject: Leukoplakia, Oral / Lip Neoplasms / Mouth Neoplasms / Carcinoma, Squamous Cell / Apoptosis / Caspase 3 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal Fluminense/BR