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Estrogen deficiency in ovariectomized rats: can resistance training re-establish angiogenesis in visceral adipose tissue?
do Valle Gomes-Gatto, Camila; Duarte, Fernanda Oliveira; Stotzer, Uliana Sbeguen; Rodrigues, Maria Fernanda Cury; de Andrade Perez, Sérgio Eduardo; Selistre-de-Araujo, Heloisa Sobreiro.
  • do Valle Gomes-Gatto, Camila; Universidade Federal de São Carlos. Laboratório de Bioquímica e Biologia Molecular. São Carlos. BR
  • Duarte, Fernanda Oliveira; Universidade Federal de São Carlos. Laboratório de Bioquímica e Biologia Molecular. São Carlos. BR
  • Stotzer, Uliana Sbeguen; Universidade Federal de São Carlos. Laboratório de Bioquímica e Biologia Molecular. São Carlos. BR
  • Rodrigues, Maria Fernanda Cury; Universidade Federal de São Carlos. Laboratório de Bioquímica e Biologia Molecular. São Carlos. BR
  • de Andrade Perez, Sérgio Eduardo; Universidade Federal de São Carlos. Laboratório de Bioquímica e Biologia Molecular. São Carlos. BR
  • Selistre-de-Araujo, Heloisa Sobreiro; Universidade Federal de São Carlos. Laboratório de Bioquímica e Biologia Molecular. São Carlos. BR
Clinics ; 71(9): 528-536, Sept. 2016. tab, graf
Article in English | LILACS | ID: lil-794640
ABSTRACT

OBJECTIVE:

The purpose of this study was to investigate the effects of resistance training on angiogenesis markers of visceral adipose tissue in ovariectomized rats.

METHOD:

Adult Sprague-Dawley female rats were divided into four groups (n=6 per group) sham-sedentary, ovariectomized sedentary, sham-resistance training and ovariectomized resistance training. The rats were allowed to climb a 1.1-m vertical ladder with weights attached to their tails and the weights were progressively increased. Sessions were performed three times per week for 10 weeks. Visceral adipose tissue angiogenesis and morphology were analyzed by histology. VEGF-A mRNA and protein levels were analyzed by real-time PCR and ELISA, respectively.

RESULTS:

Ovariectomy resulted in higher body mass (p=0.0003), adipocyte hypertrophy (p=0.0003), decreased VEGF-A mRNA (p=0.0004) and protein levels (p=0.0009), and decreased micro-vascular density (p=0.0181) in the visceral adipose tissue of the rats. Resistance training for 10 weeks was not able to attenuate the reduced angiogenesis in the visceral adipose tissue of the ovariectomized rats.

CONCLUSION:

Our findings indicate that the resistance training program used in this study could not ameliorate low angiogenesis in the visceral adipose tissue of ovariectomized rats.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Physical Conditioning, Animal / Ovariectomy / Neovascularization, Physiologic / Intra-Abdominal Fat / Estrogens / Resistance Training Type of study: Evaluation studies Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2016 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Carlos/BR

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Full text: Available Index: LILACS (Americas) Main subject: Physical Conditioning, Animal / Ovariectomy / Neovascularization, Physiologic / Intra-Abdominal Fat / Estrogens / Resistance Training Type of study: Evaluation studies Limits: Animals Language: English Journal: Clinics Journal subject: Medicine Year: 2016 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Carlos/BR