Clinical features and outcomes of diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis in children
Clinics
;
71(9): 550-554, Sept. 2016. tab, graf
Article
in English
| LILACS
| ID: lil-794644
ABSTRACT
OBJECTIVE:
To investigate the outcomes of childhood diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis (DEP-HSPN) in response to early diagnosis and prompt treatment.METHODS:
Eleven cases of DEP-HSPN in children were investigated in comparison to HSPN without diffuse endocapillary proliferation (non-DEP-HSPN).RESULTS:
DEP-HSPN had a higher prevalence of nephrotic syndrome but a lower prevalence of hematuria compared to non-DEP-HSPN. IgA, IgG and IgM antibody deposition was found in DEP-HSPN by histopathological examination. Proteinuria cleared in all 11 cases through treatment with steroids and/or immunosuppressive drugs. However, half of the DEP-HSPN patients continuously had hematuria after treatment.CONCLUSION:
The early diagnosis and prompt initiation of immunosuppressive treatment based on renal biopsy are important for achieving favorable outcomes.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
IgA Vasculitis
/
Nephritis
Type of study:
Risk factors
/
Screening study
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2016
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Zhejiang University/CN
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