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Lymphangiogenesis and angiogenesis in oral cavity and lower lip squamous cell carcinoma / Linfangiogênese e angiogênese em carcinomas de células escamosas de lábio inferior e da cavidade oral
Alaeddini, Mojgan; Etemad-Moghadam, Shahroo.
  • Alaeddini, Mojgan; Tehran University of Medical Sciences. Dentistry Research Institute. Dental Research Center. Tehran. IR
  • Etemad-Moghadam, Shahroo; Tehran University of Medical Sciences. Dentistry Research Institute. Dental Research Center. Tehran. IR
Braz. j. otorhinolaryngol. (Impr.) ; 82(4): 385-390, July-Aug. 2016. tab, graf
Article in English | LILACS | ID: lil-794975
Responsible library: BR1.1
ABSTRACT
ABSTRACT

INTRODUCTION:

Tumors of the lip and oral cavity differ in various aspects; therefore a clarification of the distinctions among these sites may help to better understand the biologic behavior of neoplasms occurring in these locations.

OBJECTIVE:

Considering that angiogenesis and lymphangiogenesis are two major elements that can influence various aspects of tumor biology, we aimed to compare these factors between squamous cell carcinoma of the lower lip and oral cavity.

METHODS:

A total of 84 primary squamous cell carcinomas including 45 oral and 39 lower lip tumors were selected and immunohistochemically stained with monoclonal antibody against D2-40 and CD105. Mean microvessel density was assessed in tumoral tissue, while lymphatic vessel density was calculated in both neoplastic tissue and invasion front. Data were statistically analyzed using t-test and p-values of <0.05 were considered significant.

RESULTS:

We found a mean microvessel density ± standard deviation of 31.94 ± 18.9 in oral cavity and 27.54 ± 20.8 in lower lip squamous cell carcinomas, with no significant difference (p = 0.32). Mean lymphatic vessel density ± standard deviation was 13.05 ± 8.2 and 16.57 ± 10.79 in of oral cavity and lower lip neoplastic tissue, respectively. The corresponding values were 9.94 ± 5.59 and 12.50 ± 7.8 in the invasive front. Significant differences were not observed in either of the lymphatic vessel density variables between the two sites.

CONCLUSION:

According to our results, it seems that the search for additional factors other than those related to the vasculature should continue, to help clarify the differences in biologic behavior between lower lip and oral cavity squamous cell carcinomas.
RESUMO
Resumo

Introdução:

Os tumores de lábio e da cavidade oral diferem em vários aspectos; portanto, o conhecimento das diferenças entre eles pode ajudar na melhor compreensão do comportamento biológico das neoplasias que ocorrem nesses locais.

Objetivo:

Considerando que a angiogênese e a linfangiogênese são dois elementos importantes que podem influenciar diversos aspectos da biologia dos tumores, objetivamos comparar esses fatores entre o carcinoma de células escamosas (CCE) de lábio inferior e da cavidade oral.

Método:

No total, foram selecionados 84 CCEs primários (45 tumores da cavidade oral e 39 tumores de lábio). Esses tumores foram corados por processo imunohistoquímico com anticorpo monoclonal anti-D2-40 e CD105. Avaliamos a densidade média de microvasos (DMV) no tecido tumoral, enquanto que a densidade vascular linfática (DVL) foi calculada tanto no tecido neoplásico como no front de invasão. Os dados foram estatisticamente analisados com o uso do teste t e valores de p < 0,05 foram considerados significantes.

Resultados:

Chegamos a uma média para DMV ± DP de 31,94 ± 18,9 para CCEs na cavidade oral e de 27,54 ± 20,8 no lábio inferior, sem diferença significante (p = 0,32). As médias para DVL ± DP foram de 13,05 ± 8,2 e 16,57 ± 10,79 no tecido neoplásico da cavidade oral e lábio inferior, respectivamente. Os valores correspondentes foram 9,94 ± 5,59 e 12,50 ± 7,8 no front invasivo. Não foram observadas diferenças significantes nas duas variáveis DVL entre os dois locais.

Conclusão:

De acordo com os nossos resultados, a pesquisa por fatores adicionais, além daqueles relacionados à vasculatura, deve ter continuidade, para auxiliar no esclarecimento das diferenças do comportamento biológico entre CCEs no lábio inferior e na cavidade oral.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Lip Neoplasms / Mouth Neoplasms / Carcinoma, Squamous Cell / Lymphangiogenesis / Neovascularization, Pathologic Type of study: Observational study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2016 Type: Article Affiliation country: Iran Institution/Affiliation country: Tehran University of Medical Sciences/IR

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Full text: Available Index: LILACS (Americas) Main subject: Lip Neoplasms / Mouth Neoplasms / Carcinoma, Squamous Cell / Lymphangiogenesis / Neovascularization, Pathologic Type of study: Observational study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Braz. j. otorhinolaryngol. (Impr.) Journal subject: Otolaryngology Year: 2016 Type: Article Affiliation country: Iran Institution/Affiliation country: Tehran University of Medical Sciences/IR