Adipose tissue stromal vascular fraction in the treatment of full thickness burns in rats
Acta cir. bras
;
31(9): 578-585, Sept. 2016. tab, graf
Article
in English
| LILACS
| ID: lil-795994
ABSTRACT
ABSTRACT PURPOSE:
To analyze the healing effects of stromal vascular fraction (SVF) application compared to wound dressing with 2% silver sulfadiazine in full thickness burn wounds in rats.METHODS:
Animals were divided into two groups 2% silver sulfadiazine group and SVF group. Both groups received occlusive bandages while the first one was treated with 2% silver sulfadiazine and the latter was treated with injections of SVF prepared from adipose tissue extracted from an animal donor. The animals were accompanied through 3, 7 and 30 days for evaluation of macroscopic, microscopic and morphometric aspects.RESULTS:
On day three, a significant increase (p<0.05) of infiltration of polymorphonuclear, fibrin formation and fibroblasts migration in SVF group was observed. On the 7th day the mononuclear infiltrate, angiogenesis, collagen and fibroblasts were significantly increased in the SVF group (p<0.05). At 30 days significantly increased collagen deposition was observed in the SVF group (p<0.05) .CONCLUSION:
Adipose tissue derived stromal vascular fraction injections promotes better wound repair than 2% silver sulfadiazine in the treatment of full thickness burn in rats during the evaluated experimental period.
Full text:
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Index:
LILACS (Americas)
Main subject:
Silver Sulfadiazine
/
Wound Healing
/
Burns
/
Adipose Tissue
/
Anti-Infective Agents, Local
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2016
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Goiás/BR
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