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The involvement of endothelial mediators in leprosy
Nogueira, Maria Renata Sales; Latini, Ana Carla Pereira; Nogueira, Maria Esther Salles.
  • Nogueira, Maria Renata Sales; Secretaria de Estado da Saúde. Instituto Lauro de Souza Lima. Divisão de Pesquisa e Ensino. Bauru. BR
  • Latini, Ana Carla Pereira; Secretaria de Estado da Saúde. Instituto Lauro de Souza Lima. Divisão de Pesquisa e Ensino. Bauru. BR
  • Nogueira, Maria Esther Salles; Secretaria de Estado da Saúde. Instituto Lauro de Souza Lima. Divisão de Pesquisa e Ensino. Bauru. BR
Mem. Inst. Oswaldo Cruz ; 111(10): 635-641, Oct. 2016. tab, graf
Article in English | LILACS | ID: lil-796907
ABSTRACT
Leprosy is a chronic infectious disease that requires better understanding since it continues to be a significant health problem in many parts of the world. Leprosy reactions are acute inflammatory episodes regarded as the central etiology of nerve damage in the disease. The activation of endothelium is a relevant phenomenon to be investigated in leprosy reactions. The present study evaluated the expression of endothelial factors in skin lesions and serum samples of leprosy patients. Immunohistochemical analysis of skin samples and serum measurements of VCAM-1, VEGF, tissue factor and thrombomodulin were performed in 77 leprosy patients and 12 controls. We observed significant increase of VCAM-1 circulating levels in non-reactional leprosy (p = 0.0009). The immunostaining of VEGF and tissue factor was higher in endothelium of non-reactional leprosy (p = 0.02 for both) than healthy controls. Patients with type 1 reaction presented increased thrombomodulin serum levels, compared with non-reactional leprosy (p = 0.02). In type 2 reaction, no significant modifications were observed for the endothelial factors investigated. The anti-inflammatory and antimicrobial activities of the endotfhelial factors may play key-roles in the pathogenesis of leprosy and should be enrolled in studies focusing on alternative targets to improve the management of leprosy and its reactions.
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Full text: Available Index: LILACS (Americas) Main subject: Skin / Thromboplastin / Thrombomodulin / Vascular Cell Adhesion Molecule-1 / Vascular Endothelial Growth Factor A / Leprosy Limits: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Secretaria de Estado da Saúde/BR

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Full text: Available Index: LILACS (Americas) Main subject: Skin / Thromboplastin / Thrombomodulin / Vascular Cell Adhesion Molecule-1 / Vascular Endothelial Growth Factor A / Leprosy Limits: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Secretaria de Estado da Saúde/BR