The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate
J. appl. oral sci
;
24(5): 423-430, Sept.-Oct. 2016. graf
Article
in English
| LILACS, BBO
| ID: lil-797985
ABSTRACT
ABSTRACT Objective:
To investigate the effect of HRE (Hippophae rhamnoides extract) on oral mucositis induced in rats with MTX. Material andMethods:
Experimental animals were divided into groups as healthy (HG), HRE+MTX (HMTX), and control group, which received MTX (MTXC). HMTX group received 50 mg/kg HRE while MTXC and HG groups received equivolume distilled water with gavage once a day. After one hour of HRE and distilled water administration, HMTX and MTXC groups received a single dose of oral MTX 5 mg/ kg. This procedure was repeated for one month.Results:
The levels of MDA, IL-1β, and TNF-α were found to be significantly higher in the cheek, lower lip, and tongue tissue of the animals receiving MTX, compared with HG and HMTX groups; however, these parameters were lower in the cheek and low lip tissue, and a milder damage ocurred in these tissues, compared with the tongue tissue in MTXC group. No histopathologic damage was observed in the cheek, lower lip, and tongue tissues of the rats treated with HRE.Conclusion:
This findings indicate that HRE as a natural product is an important advantage compared with synthetic drugs for prophylaxis of oral mucositis developed due to MTX.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Stomatitis
/
Plant Extracts
/
Methotrexate
/
Hippophae
/
Folic Acid Antagonists
Type of study:
Evaluation studies
Limits:
Animals
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2016
Type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Erzurum Education and Research Hospital/TR
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