Vitamin E stimulates endotoxin-inhibited monocyte migration and phagocytosis in vivo
Braz. j. med. biol. res
;
22(11): 1401-3, 1989. ilus
Article
in English
| LILACS
| ID: lil-83146
ABSTRACT
Intravenous administration of E. coli endotoxin (LPS, 30 microng/kg, iv) inhibited thioglycollatestimulated accumulation of monocytes into the rat peritoneal cavity, measured 48 and 72 h later, by about 40%. Pretreatment of animals with vitamin E (50 mg/kg, im) restored thioglycollate-induced monocyte migration in LPS-challenged rats to control levels. Vitamin E also partially reversed LPS-induced inhibition of monocyte phagocytosis in vivo. The results suggest that vitamin E could be beneficial in restoring leukocyte function in septicemic states
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Index:
LILACS (Americas)
Main subject:
Peritoneal Cavity
/
Phagocytosis
/
Vitamin E
/
Cell Migration Inhibition
/
Monocytes
/
Endotoxins
/
Escherichia coli
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
/
Project document
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