Effects of ipsapirone and BAY R 1531 on learned helplessness
Braz. j. med. biol. res
;
22(9): 1141-4, 1989. ilus
Article
in English
| LILACS
| ID: lil-83191
ABSTRACT
The effects of the 5-hydroxytryptamine-1A (5-HT1A) receptor agonists on the learned helplessness test were investigated. Rats were submited to a single session of 60 uncontrollable shocks (10-s duration, 1.0 mA, every 60 + or - 40 s) and then treated twice daily with ip ijections of either ipsapirone (13 mg/kg daily) or BAY R 1531 (0.375 mg/kg daily) for four consecutive days. On the last day, the animals were submitted to an escap test. The results showed that both drug treatments blocked the deficit in the escape learning (helplessness effect). These data suggest that drugs which stimulate 5-HT1A receptors have an antidepressant-like activity in this animal model of depression
Search on Google
Index:
LILACS (Americas)
Main subject:
Pyrimidines
/
Receptors, Serotonin
/
Electroshock
/
Escape Reaction
/
Helplessness, Learned
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
/
Congress and conference
/
Project document
Similar
MEDLINE
...
LILACS
LIS