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Chemotactic effect of PAF-acether on peritoneal eosinophils from normal rats
Braz. j. med. biol. res ; 22(9): 1151-4, 1989. ilus
Article in English | LILACS | ID: lil-83193
ABSTRACT
The chemotactic activity of PAF-acether was compared with that of tetrapeptide eosinophil chemotactic factors of anaphylaxis (ECF-A, Ala-Gly-Ser Glu and Val-Gly-Ser-Glu) using eosinophils obtained from the peritoneal cavity of normal rats. Cells were isolated by separation over discontinuous metrizamide gradients which resulted in eosinophil suspensions of 80 to 90% purity. PAF-acether produced 7-fold greater than the maximal activity obtained with the ECF-A-tetrapeptides. BN 52021 and WEB 2086 inhibited PAF-acether-induced eosinophil chemotaxis in a dose-dependent manner, suggesting that this phenomenon is mediated by specific PAF-acether receptors
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Index: LILACS (Americas) Main subject: Peritoneal Cavity / In Vitro Techniques / Platelet Activating Factor / Chemotactic Factors, Eosinophil / Eosinophils Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1989 Type: Article / Congress and conference

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Index: LILACS (Americas) Main subject: Peritoneal Cavity / In Vitro Techniques / Platelet Activating Factor / Chemotactic Factors, Eosinophil / Eosinophils Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1989 Type: Article / Congress and conference