The cholinergic and dopaminergic systems of the prelimbic sector of frontal cortex and memory in the rat
Braz. j. med. biol. res
;
22(9): 1155-8, 1989. tab
Article
in English
| LILACS
| ID: lil-83194
ABSTRACT
Rats were trained to perform delayed non-matching to sample (a working/representational memory task) and visual discrimination(a reference/dispositional memory task) in a T-maze, and implanted bilaterally with cannulae in the prelimbic cortex. The rats were tested postoperatively after bilateral 1 - micronl injections of vehicle (Krebs-Ringer), sulpiride (10 microng/micronl) or scopolamine (18 microng/micronl). Sulpiride had no effect on the performance of either task, whereas scopolamine interfered only with the performance of delayed non-matching to sample. We conclude that dopaminergic mechanisms in the prelimbic cortex are not involved in either type of memory and that cholinergic, but not dopaminergic, mechanisms are important for working/representational memory process
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Index:
LILACS (Americas)
Main subject:
Scopolamine
/
Sulpiride
/
Frontal Lobe
/
Memory
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
/
Congress and conference
/
Project document
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