Effect of chlorpromazine and biliary drainage on portal blood flow and mitochondrial function during extrahepatic cholestasis

Roselino, J. E. S; Silva Júnior, Orlando Castro e; Romanello, L. M. F; Ceneviva, Reginaldo

Roselino, J. E. S; Silva Júnior, Orlando Castro e; Romanello, L. M. F; Ceneviva, Reginaldo.

Braz. j. med. biol. res ; 22(7): 889-93, 1989. tab

Article in English | LILACS | ID: lil-83241

ABSTRACT

ABSTRACT

The present study examines the effect of chlorpromazine and biliary drainage in cholestatic rats. The time course of portal blood flow was studied 24,48, and 72 h and seven days after bile duct ligation. Portal blood flow decreased after 72 h. Chlorpromazine reduced biliary hydrostatic pressure in sham-operated control rats, but 24-h obstruction was sufficient to prevent this effect in cholestatic rats. The drug ameliorated the mitochondrial and cell membrane function of cholestatic rats before and after drainage. The data present further support for the role of ischemia in cholestasis

Subject(s)

Rats; Animals; Male; Bile Ducts/surgery; Chlorpromazine/pharmacology; Cholestasis, Extrahepatic/physiopathology; Liver Circulation; Mitochondria, Liver/physiology; Alanine Transaminase/blood; Drainage; Hydrostatic Pressure; Ischemia/etiology; Rats, Inbred Strains

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Index: LILACS (Americas) Main subject: Cholestasis, Extrahepatic / Bile Ducts / Mitochondria, Liver / Chlorpromazine / Liver Circulation Type of study: Etiology study Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1989 Type: Article / Congress and conference / Project document

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