Gossypol affects the responsiveness of isolated rat myometrium and vas deferens
Braz. j. med. biol. res
;
22(10): 1287-90, 1989. ilus
Article
in English
| LILACS
| ID: lil-83391
ABSTRACT
The effects of gossypol on responsiveness of both rat myometrium and vas deferens were analyzed. In myometrial strips, gossypol (1-30 micronM) produced rightward displacemtns of the cumulative concentration-response curves to acetylcholine, bradykinin and oxytocin, accompanied by reductions in maximal responses. Gossypol (30 micronM) also completely abolished the contractions induced by field stimulation of the rat vas deferens. The IC50 values for gossypol against agonist-uinduced myometrial contractions and field-stimulated vas deferens contractions were similar, ranging between 13 and 18 micronM. These results provide additional evidence that gossypol exerts a direct and irreversible inhibition of the contractility of both male and female reproductive organs
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Index:
LILACS (Americas)
Main subject:
Uterine Contraction
/
Vas Deferens
/
Gossypol
/
Muscle Contraction
/
Myometrium
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1989
Type:
Article
/
Congress and conference
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