Effect of cisplatin on glomerular hemodynamics

ABSTRACT

The effects of cisplatin on renal microcirculation were evaluated in euvolemic Munich-Wistar rats submitted to micropuncture. Nine rats received a single dose of cisplatin (6 mg/kg,ip), and 6 control rats received the same volume (0.3 ml) of 15 mM NaCl 4 days before the measurements. Cisplatin administration induced non-oliguric acute renal failure by decreasing glomerular filtration rate (GFR) from 0.96 + or- 0.5 to 0.33 + or - 0.04 ml/min (P<0.05) and by increasing urinary volume from 3.3 + or - 0.3 to 12.4 + or - 2.2 micronl/min (P<0.05). Cisplatin administration decreased single nephron GFR from 34.2 + or - 2.1 to 20.1 + or - 2.3 nl/min (P<0.05) due to a reduction in both glomerular plasma flow from 106 + or - 9 to 61 + or - 6 nl/min (P<0.05) and transcapillary hydraulic pressure difference from 31 + or - 1 to 27 + or - 1 mmHg (P<0.05). An increase in arteriolar resistances, mainly afferent arteriolar resistance from 2.5 + or - 0.2 to 4.7 + or - 0.5 x 10**10 dyn.s.cm**-5 (P<0.05), was observed. The glomerular ultrafiltration coefficient was unchanged