Substance P and naloxone enhancement of avoidance conditioning in rats
Braz. j. med. biol. res
;
23(2): 163-7, 1990. tab
Article
in English
| LILACS
| ID: lil-85153
ABSTRACT
Experiments were carried out to investigate the effects of peripheral post-training administration of substance P (SP) and naloxone on learning. Rats were trained in three different avoidance tasks (uphill, step-down and alcove) and tested 24 h later. Thirty minutes before each trial (training and testing) rats received naloxone (0.5, 1, 5, or 50 mg/kg, ip) or saline. SP (50 microng/kg) or vehicle was administered ip immediately after training. Animals that received SP and SP in combination with naloxone (5 and 50 mg/kg) showed significantly better retention test performance for the uphill and step-down avoidance (P < 0.05 when compared to control rats treated with vehicle). In the alcove task no influence of SP and/or naloxone was demonstrable, probably due to a ceiling effect. These results suggest that the memory enhancement effects observed are mediated, at least in part, via interactions between substance P and the endogenous opioid systems
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Index:
LILACS (Americas)
Main subject:
Retention, Psychology
/
Avoidance Learning
/
Substance P
/
Conditioning, Psychological
/
Naloxone
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1990
Type:
Article
/
Project document
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