Bilateral microinjection of ethosuximide into the substantia nigra does not prevent amygdala-kindled seizures
Braz. j. med. biol. res
;
23(11): 1139-41, 1990. tab
Article
in English
| LILACS
| ID: lil-91615
ABSTRACT
Male Wistar rats were sugjected to daily sessions of electrical amygdala kindling until a generalized seixure was observed on five consecutive days. Bilateral microinections (0.5 micronl) of ethosuximide (ETX) (10 pg/micronl) or saline were then administered though guide cannulas into the substantia nigra (pars reticulata). No significant difference was observed between the ETX (N = 8) and saline (N = 8) groups in duration of afterdischarge or in the latency for stage 5 generalized seizures. Our results indicate that ETX applied to the substantia nigra is not effective in suppressing amydala-kindled seizure
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Index:
LILACS (Americas)
Main subject:
Seizures
/
Substantia Nigra
/
Ethosuximide
/
Amygdala
/
Kindling, Neurologic
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1990
Type:
Article
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