Nesidioblastosis associated with chronic experimental pancreatitis produced by a scorpion toxin, tityustoxin, in rats

Novaes, G; Queiroz, Aristides Chetto de; Cardoso, C. de Carvalho; Carvalho, M. H. Burlacchini de; Ribeiro Filho, L. A; Gonçalves, A. Oliveira

Novaes, G; Queiroz, Aristides Chetto de; Cardoso, C. de Carvalho; Carvalho, M. H. Burlacchini de; Ribeiro Filho, L. A; Gonçalves, A. Oliveira.

Braz. j. med. biol. res ; 23(11): 1149-51, 1990. ilus

Article in English | LILACS | ID: lil-91617

ABSTRACT

ABSTRACT

Tityustoxin (TsTx), the purified venom of the Brazilian scorpion Tityus serrulatus, was inected intravenously (50 microng/Kg) into rats, producing a typical picture of chronic pancreatitis after 20 days. Nesidioblastosis, a lesions characterized by hyperplasia of the islets of Langerhans, was also detected in a high percentage (40%) of animals. TsTx-induced pancreatitis may be a useful model for the study of nesidioblastosis in laboratory animals

Subject(s)

Rats; Animals; Male; Neurotoxins/toxicity; Pancreatic Diseases/pathology; Pancreatitis/chemically induced; Scorpion Venoms/toxicity; Chronic Disease; Injections, Intravenous; Pancreatitis/pathology; Scorpion Venoms/administration & dosage

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Index: LILACS (Americas) Main subject: Pancreatic Diseases / Pancreatitis / Scorpion Venoms / Neurotoxins Type of study: Prognostic study / Risk factors Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1990 Type: Article / Congress and conference

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