Effects of chronic treatment with high doses of chlorpromazine on ATP and ADP hydrolysis by synaptosomal fractions from the rat caudate nucleus
Braz. j. med. biol. res
;
23(10): 969-73, 1990. tab
Article
in English
| LILACS
| ID: lil-91634
ABSTRACT
Several studies have indicated that chlorpromazine and its metabolites affect ATP hydrolysis by brain and liver plasma membranes in vitro. The present report examines whether chronic treatment (12 days) with high doses of chlorpromazine (10 and 40 mg/kg) could affect ATP and ADP hydrolysis by synaptosomal fractions from the rate caudate nucleus. Both doses of chlorpromazine caused significant and paralled decreases (23 to 31%) in the ATP and ADP hydrolysis. The parallelism between the effects of chlorpromazine on ATP and ADP hydrolys suggests the participation of a single enzyme (ATP diphosphohydrolase) in nucleotide hydrolysis
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Index:
LILACS (Americas)
Main subject:
Synaptosomes
/
Caudate Nucleus
/
Adenosine Diphosphate
/
Adenosine Triphosphate
/
Chlorpromazine
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1990
Type:
Article
/
Congress and conference
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