Pleural eosinophil infiltration induced by PAF-acether is not a desensitizable phenomenon
Braz. j. med. biol. res
;
23(10): 1009-13, 1990. ilus
Article
in English
| LILACS
| ID: lil-91642
RESUMO
This study investigated the effect of successive daily intrathoracic (it) injections of PAF-acether upon its demonstrated ability to generate eosinochemotaxin(s). Repeated administration of PAF-acether led to a selective state of desensitization, characterized by a gradual reduction of its ability to induce exudation. Concomitantly, however, there was a progressive pleural accumulation of eosinophilis leading to a 7-fold increase in the eosinophil counts after the 4th restimulation. The generation of eosinochemotaxin(s) elicited by PAF-acether was not modified by desensitization, as detected by transferring the cell-free pleural fluid from donor to recipient animals. We conclude that, in contrast to exudation, eosinophil tissue infiltration induced by PAF-acether is not a desensitizable phenomenon
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Index:
LILACS (Americas)
Main subject:
Pleural Effusion
/
Platelet Activating Factor
/
Eosinophilia
/
Eosinophils
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1990
Type:
Article
/
Congress and conference
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