Effect of sex steroids on the circulating levels of alfa2-macroglobulin in injured rats
Braz. j. med. biol. res
;
23(10): 1021-4, 1990. tab
Article
in English
| LILACS
| ID: lil-91644
RESUMO
The effect of sex steroids on the plasma levels of alfa2-macroglobulin (alfa-2M) was investigated to explain the sexual dimorphism observed in response to the injuries caused by ip administration of 5 microng endotoxin. Mean serum alfa2-M concentrations were lower in female (46.82 ñ8.10 arbitrary units) than in male injured rats (82.94 ñ 9.22 arbitrary units). a reduction of plasma alfa2-M levels was observed after orchidectomy, and the administration of 1 mg testosterone to the same animals increased the response. The same response pattern wa observed in ovariectomized rats under the same treatment. The response of androgenized rats (78.93 ñ 12.81 arbitrary units) to injury was similar to the male response. These results suggest the importance of testosterone as the major determinant of this sex-dependent response
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Index:
LILACS (Americas)
Main subject:
Gonadal Steroid Hormones
/
Alpha-Macroglobulins
/
Sex Characteristics
/
Acute-Phase Reaction
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1990
Type:
Article
/
Congress and conference
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