Inhibition of gastric acid secretion by cholinergic stimulation of the lateral hypopthalamic area

Gontijo, J. A. R; Silva Netto, C. R; Furtado, M. R. F

Gontijo, J. A. R; Silva Netto, C. R; Furtado, M. R. F.

Braz. j. med. biol. res ; 23(3/4): 361-5, 1990. ilus, tab

Article in English | LILACS | ID: lil-91758

ABSTRACT

ABSTRACT

Cholinergic stimulation of the lateral hypothalamic area with carbachol (1 microng in 1 micronl) markedly inhibited gastric acid secretion in the anesthetized rat. Inhibition was bloced by prior microinjection of atropine (4 microng/micronl) into the same brain area and was accompanied by an increased soldium content in the stomach. Muscarinic receptor mediated cholinergic inhibitory influence of the hypothalamus on gastric acid secretion is suggested by these

results:

Subject(s)

Animals; Rats; Male; Gastric Acid; Atropine/pharmacology; Carbachol/pharmacology; Hypothalamus/physiology; Histamine/pharmacology; Atropine/administration & dosage; Carbachol/administration & dosage; Histamine/administration & dosage; Rats, Wistar

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Index: LILACS (Americas) Main subject: Atropine / Carbachol / Histamine / Gastric Acid / Hypothalamus Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1990 Type: Article

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