GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures
Braz. j. med. biol. res
;
23(6/7): 555-8, 1990. ilus
Article
in English
| LILACS
| ID: lil-92202
ABSTRACT
In the present glutamate decarboxylase immunoreactivity (GAD-IR) was used to quantify GABAergic neurons in the hippocampus of rats exhibiting spontaneous recurtent seizures following pilocarpine-induced status epilepticus. Histological examination demonstrated marked neuronal damage to hippocampal neurons. However, in the same region, GAD-IR neurons were preserved. the present data demonstrate a selective resistance of GABAergic neurons to status epilepticus-induced neuronal damage, suggesting that loss of hippocampal GABAergic neurons does not underlie the recurrence of seizures in these animals
Search on Google
Index:
LILACS (Americas)
Main subject:
Pilocarpine
/
Seizures
/
Status Epilepticus
/
Epilepsies, Partial
/
Gamma-Aminobutyric Acid
/
Glutamate Decarboxylase
/
Hippocampus
/
Neurons
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1990
Type:
Article
/
Congress and conference
Similar
MEDLINE
...
LILACS
LIS