Correlation between the lack of mononuclear cell cytotoxicity against schistosomula in vitro with schistosomiasis
Braz. j. med. biol. res
;
23(6/7): 577-80, 1990. tab
Article
in English
| LILACS
| ID: lil-92206
ABSTRACT
A comparison was made of the reactivity of mononuclear cells from subjects and from S. mansoni-infected patients. The following parameters were evaluated 1) ability of mononuclear cells to kill schistosoma in the presence of complement; 2) [3H]-inositol incorporation into phosphatidylinositol (PI) and the rate of inositolphosphates (IPx) released. Cells from normal subjects, but not from S. mansoni infected patients, were able to kill schistosomula in vitro. A decrease in inositolpolyphosphates (IPx) was observed for phytohemagglutinin (PHA)-stimulated mononuclear cells from infected patients when compared with mononuclear cells from normal subjects after 24 h of incubation. The results suggest that the reactivity of mononuclear cells from infected patients is altered under conditions of nonspecific stimulation with PHA when compared with normal cells
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Index:
LILACS (Americas)
Main subject:
Phytohemagglutinins
/
Schistosomiasis mansoni
/
In Vitro Techniques
/
Leukocytes, Mononuclear
/
Inositol Phosphates
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1990
Type:
Article
/
Congress and conference
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