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Preliminary results corroborating the polygenic control of immunological tolerance
Braz. j. med. biol. res ; 23(6/7): 581-4, 1990. ilus, tab
Article in English | LILACS | ID: lil-92207
ABSTRACT
Tolerance-susceptible (TS) and-resistant (TR) lines of mice are in the process of bidirectional genetic selection starting from a genetically hetrogeneous population achieved by the equilibrated intercrossing of eight inbred lines. Mice are intragastrically pretreated and then immunized with hen ovalbumin or bovine serum albunin and the extreme phenotypes are selected for assortative mating. The normal distribution of agglutinin titers in the F0 population and the significant interline difference already observed in the F2 and F3 generations indicate that oral tolerance is a character controlled by the additive effect of several independet loci. The mean heritability (h2) obtained thus far is 11% for the TS line and 19% for the TR line
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Index: LILACS (Americas) Main subject: Selection, Genetic / Immunization, Passive / Gene Frequency / Immune Tolerance Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1990 Type: Article / Congress and conference

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Index: LILACS (Americas) Main subject: Selection, Genetic / Immunization, Passive / Gene Frequency / Immune Tolerance Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1990 Type: Article / Congress and conference