Indomethacin affects the development of tolerance to ethanol-induced diuresis
Braz. j. med. biol. res
; 23(8): 701-3, 1990. tab, ilus
Article
in En
| LILACS
| ID: lil-92279
Responsible library:
BR26.1
ABSTRACT
The present study analyzes the effects of indomethacin on the development of tolerance to the diuretic effect of ethanol. Male Wistar rats were with ethanol (2gKg-1 day-1) over a period of 4 weeks and the effect of ethanol on diuresis was assessed weekly. A significant tolerance to the diuretic effect of ethanol was detected after 3 weeks of treatment. However, rats treatment simultaneously with ethanol plus indomethacin (5mg/Kg, ip,, on alternate days) showed no tolerance to ethanol even after 4 weeks of treatment. The fact that indonethacin prevented the development of tolerance to the diuretic effect of ethanol but no influence on diuresis per se suggests that prostaglandins play a significant role in the mechanisms of tolerance to ethanol
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Index:
LILACS
Main subject:
Prostaglandins
/
Indomethacin
/
Diuresis
/
Ethanol
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1990
Type:
Article
/
Congress and conference