Pituitary-testicular axis in benznidazole-treated rata
Braz. j. med. biol. res
;
23(8): 719-22, 1990. tab
Article
in English
| LILACS
| ID: lil-92329
RESUMO
Benznidazole is used extensively throughout Latin America as an antiparasitic chemotherapeutic agent against chagasica infection. We have shown that rats chronically treated with 80 mg benznidazole Kg-1 day-1 for 30, days present severe testicular atrophy and arrest of spermatognesis. In the present experiments, plasma levels of testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (Prl- were inbestigated in rats receiving 10, 40 and 80 mg benznidazole Kg-1 day-1 for 30 days. No significant change in T, LH or Prl levels was observed in treated rats (P > 0.05). Plasma FSH concentration, however, was markedly invreased (P < 0.05 by benzidazole treatment (40 and 80 mgKg-1 day-1) and remained high for 90 days after drug treatment was discontinued
Search on Google
Index:
LILACS (Americas)
Main subject:
Prolactin
/
Testosterone
/
Benzimidazoles
/
Luteinizing Hormone
/
Follicle Stimulating Hormone
/
Antiprotozoal Agents
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1990
Type:
Article
/
Congress and conference
Similar
MEDLINE
...
LILACS
LIS