Thyroidectiomy reduces stress-induced prolactin secretion in rats. Participation of brain serotonergic systems

ABSTRACT

Plasma prolactin levels were measusred in thyroidectomized and sham-operated rats under immobilization stress. thyroidectomy significantly reduced prolactin secretion during stress. The pretreatment of thyroidectomized rats with 6-chloro-2[1-piperazinyl]-pyrazine (MK 212), a serotinin agonist that easily penetrates the blood-brain barrier, reversed the reduction in stress-induced prolactin release in the thyroidectomized group