Seleçäo por meio de células KB de substâncias e extratos potencialmente ativos em quimioterapia do câncer

Fávaro, Osvaldo César Novais; Oliveira, Marilda Meirelles de; Rossini, Marília Almeida Antunes; Kamakura, Célia Regina; Pinto, Antônio Ventura; Pinto, Maria do Carmo F. R

Seleçäo por meio de células KB de substâncias e extratos potencialmente ativos em quimioterapia do câncer / Selection by means of KB cells of substances and extracts potentially active in cancer chemotherapy

Fávaro, Osvaldo César Novais; Oliveira, Marilda Meirelles de; Rossini, Marília Almeida Antunes; Kamakura, Célia Regina; Pinto, Antônio Ventura; Pinto, Maria do Carmo F. R.

An. acad. bras. ciênc ; 62(3): 217-24, set. 1990. tab

Article in Portuguese | LILACS | ID: lil-92524

RESUMO

RESUMO

Several synthetic, semi-synthetic and natural compounds as well extracts were screened for their growht inhibition activity on KB cells. The most active ones were naphthoquinones and derivatives of pyrido [4,3-b] carbazole alkaloids, with inhibition dose (ID50) < 4microng/ml. Of the crude extracts of several plants screened, Vellozia caput-ardeae showed to be the most active

Subject(s)

Antineoplastic Agents, Phytogenic/isolation & purification; KB Cells; Antineoplastic Agents, Phytogenic/chemistry; Antineoplastic Agents, Phytogenic/pharmacology; Drug Screening Assays, Antitumor

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Index: LILACS (Americas) Main subject: KB Cells / Antineoplastic Agents, Phytogenic Language: Portuguese Journal: An. acad. bras. ciênc Journal subject: Science Year: 1990 Type: Article

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