A syndrome of familial intrathyroidal primary parathyroid hyperplasia: case reports and critical review of literature
P. R. health sci. j
;
5(2): 55-63, Aug. 1986. tab
Article
in English
| LILACS
| ID: lil-96443
ABSTRACT
Intrathyroidal hyperplastic parathyroid glands were responsible for primary hyperparathyroidism (PHPT) in two of three members in a family. The third had an extrathyroidal parathyroidal "adenoma". Both intrathyroidal parathyroid (IThP) hyperplastic glands were the largest ones removed at the time of surgical cure. A review of the literature confirmed our postulate of a higher incidence of familial cases among patients with hyperparathyroidism and IThP with an incidence of 10.34% of IThP in familial cases versus a 4.2% in non-familial cases with PHPT. This contrasts with an incidence of 0.1% of IThP in normal patients. We hypothesize that stimulation of IThP tissue by surrounding calcitonin-producing C-cells might play a role in the seemingly preferential IThP hyperplasia. Recognition of this syndrome of Familial IthP Hyperplasia is important in order to avoid unnecessarily aggressive surgery for hyperparathyroidism
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Index:
LILACS (Americas)
Main subject:
Parathyroid Glands
/
Thyroid Neoplasms
/
Choristoma
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
P. R. health sci. j
Journal subject:
Medicine
Year:
1986
Type:
Article
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