Growth hormone in turner syndrome.
Indian Pediatr
;
2006 Mar; 43(3): 236-40
Article
in English
| IMSEAR
| ID: sea-10186
ABSTRACT
We assessed the effect of one year of therapy with recombinant Human Growth Hormone (rhGH) on growth velocity of 16 Indian girls with Turner Syndrome (TS) in a prospective, open trial. Patients received rhGH in a dose of 1 IU (0.3 mg)/kg/week. The mean pretreatment height was 117.1 cms (Z score minus 3.4), height velocity was 3.8 cm per year (Z score minus 2.4), and predicted height was 140 cm. At the end of therapy mean height was 123.9 (Z score minus 3.1), height velocity was 6.7 cm per year (Z score + 1.7), and the predicted height was 142.4 cm. The increment in height velocity with growth hormone therapy was statistically significant (P value = 0.001) and the mean increment in predicted height was 2.4 cm. Our study shows that girls with TS in India benefit from therapy with rhGH.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Turner Syndrome
/
Recombinant Proteins
/
Female
/
Humans
/
Child
/
Prospective Studies
/
Adolescent
/
Human Growth Hormone
/
Growth
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
Language:
English
Journal:
Indian Pediatr
Year:
2006
Type:
Article
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