Experimental studies on some effects of prostaglandin E2 in acute renal failure.

ABSTRACT

Acute renal failure has been produced in rats with oral administration of uranyl nitrate 40 mg/kg of body weight once, and histopathological changes in the kidneys with blood biochemical values were studied by sacrificing them after 36 hours of feeding. Prostaglandin E2 in 100 micrograms/kg of body weight was orally administered to another group of rats along with uranyl nitrate 40 mg/kg of body weight once and sacrificed them 36 hours after feeding. It was found that prostaglandin E2 has some protective effect in experimental model of acute renal failure as concluded from improved histological findings and blood biochemical values.