Diagnostic and prognostic significance of lactate dehydrogenase in cerebrospinal fluid in patients of meningitis.
J Indian Med Assoc
;
1994 Sep; 92(9): 288-90
Article
in English
| IMSEAR
| ID: sea-104236
ABSTRACT
Activity of lactate dehydrogenase was measured in cerebrospinal fluid in 60 cases of meningitis (35 pyogenic, 18 tuberculous and 7 viral). Thirty age and sex matched healthy controls were taken to find out its diagnostic and prognostic significance in meningitis. The cerebrospinal fluid lactate dehydrogenase activity was significantly higher (p < 0.001) in cases of pyogenic meningitis and tuberculous meningitis as compared to the control group. The maximum elevation was seen on the 1st day in all types of meningitis but the activity declined significantly thereafter in patients of pyogenic meningitis who recovered without complications. However, in 2 cases of pyogenic meningitis and 5 cases of tuberculous meningitis who survived with complications, the lactate dehydrogenase activity on subsequent estimations increased serially. Further, the basal lactate dehydrogenase activity in 9 cases of pyogenic meningitis (who expired) was higher than those who survived without complications. The basal lactate dehydrogenase activity in pyogenic meningitis was significantly higher (p < 0.05) as compared to tuberculous meningitis and viral meningitis patients (p < 0.02) in this study.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Prognosis
/
Female
/
Humans
/
Male
/
Case-Control Studies
/
Survival Rate
/
Sensitivity and Specificity
/
Adolescent
/
Matched-Pair Analysis
/
Adult
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Language:
English
Journal:
J Indian Med Assoc
Year:
1994
Type:
Article
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