An observational study on neurobehavioural effects of acute oxydemeton-methyl (insecticide and acaricide) exposure in rats.
Indian J Physiol Pharmacol
;
2000 Jan; 44(1): 57-63
Article
in English
| IMSEAR
| ID: sea-106182
ABSTRACT
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium-induced hypnosis after intermittent aerosol spray inhalational exposure for 1 h in rats compared to the saline control group. Further, CD50 +/- S.E.M. value for pentylenetetrazole (PTZ) and CI50 +/- S.E.M. value for electroshock (i.e. the dose of PTZ and intensity of electroshock producing positive seizure response in 50% of rats) were significantly decreased by acute exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organothiophosphorus Compounds
/
Pentylenetetrazole
/
Rats
/
Seizures
/
Barbital
/
Behavior, Animal
/
Female
/
Male
/
Rats, Sprague-Dawley
/
Convulsants
Type of study:
Observational study
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2000
Type:
Article
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