Neuropharmacological actions of some newly synthesized Mannich bases.
Indian J Physiol Pharmacol
; 1981 Jul-Sep; 25(3): 269-73
Article
in En
| IMSEAR
| ID: sea-106206
Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed any significant analgesic activity.
Full text:
1
Index:
IMSEAR
Main subject:
Pentobarbital
/
Rabbits
/
Rats
/
Receptors, Drug
/
Sensory Thresholds
/
Sleep
/
Time Factors
/
Body Temperature
/
Brain
/
Male
Language:
En
Journal:
Indian J. physiol. pharmacol
Year:
1981
Type:
Article