Neuropharmacological actions of some newly synthesized Mannich bases.

Tongia, S K; Trivedi, C P; Matkar, S V; Chouhan, R S; Kaushal, R

Tongia, S K; Trivedi, C P; Matkar, S V; Chouhan, R S; Kaushal, R.

Indian J Physiol Pharmacol ; 1981 Jul-Sep; 25(3): 269-73

Article in English | IMSEAR | ID: sea-106206

ABSTRACT

ABSTRACT

Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed any significant analgesic activity.

Subject(s)

Amines/pharmacology; Animals; Body Temperature/drug effects; Brain/drug effects; Male; Mannich Bases/pharmacology; Pentobarbital/pharmacology; Postural Balance/drug effects; Rabbits; Rats; Receptors, Drug/metabolism; Sensory Thresholds/drug effects; Sleep/drug effects; Time Factors

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pentobarbital / Rabbits / Rats / Receptors, Drug / Sensory Thresholds / Sleep / Time Factors / Body Temperature / Brain / Male Language: English Journal: Indian J Physiol Pharmacol Year: 1981 Type: Article

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