Effect of lead exposure on plasma phenylbutazone levels in rats.
Indian J Physiol Pharmacol
;
1994 Jan; 38(1): 61-2
Article
in English
| IMSEAR
| ID: sea-106223
ABSTRACT
The effect of lead exposure on phenylbutazone kinetics was studied in rats. The biological half-life (t1/2) of phenylbutazone was determined from the plasma level versus time curve in 3 groups of rats given (i) 10 mg/kg lead orally for 8 weeks (ii) 100 mg/kg single oral dose and (iii) no lead, after oral administration of 100 mg/kg phenylbutazone to all rats. The t1/2 of the drug was found to be 33% lower on chronic lead exposure and 46% higher on acute exposure than in unexposed control rats. This variation in the t1/2 values of the two different groups of rats indicates that probably phenylbutazone metabolism varies with the period of lead exposure.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Spectrophotometry, Ultraviolet
/
Male
/
Phenylbutazone
/
Half-Life
/
Lead Poisoning
/
Animals
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
1994
Type:
Article
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